When it comes to collecting human stem cells for clinical transplantation, picking the right time of day to harvest cells may result in a greater yield according to a new study.
An examination of healthy donors who were contributing HSCs for bone marrow transplantation at Mount Sinai Medical Center between the years of 2000 and 2006 revealed that the average yield was greater for those who underwent the procedure in the afternoon compared with those who were harvested in the morning.
Researchers at Mount Sinai School of Medicine were interested in examining whether circadian time continues to influence mobilization of hematopoietic stem cells (HSCs) when mice are treated with granulocyte-colony-stimulating factor (G-CSF), the most common stem cell mobilizer used in the clinic. The researchers found that after stimulation with G-CSF, synchronization of blood collection with the peak circadian time produced greater HSC recovery. Therefore, even when pharmacological manipulation is used to stimulate HSC mobilization, circadian clock genes continue to influence yield.
Adapted from the Mount Sinai School of Medicine announcement through EurekAlert.
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