Eleven independent studies show that transplanting neural stem cells into the spinal cord of an ALS mouse model slows disease onset and progression, improves motor function, and significantly prolongs survival.
The transplanted neural stem cells did not benefit ALS mice by replacing deteriorating nerve cells. Instead, neural stem cells help by producing factors that preserve the health and function of the host’s remaining nerve cells. They also reduce inflammation and suppress the number of disease-causing cells in the host’s spinal cord.
Read further in the Sanford Burnham Medical Research Institute announcement.
Note: Neuralstem Inc. (CUR), one of our Sector Companies, is preparing for a phase II clinical trial involving transplanted neural stem cells for ALS.